Dr Simon G.D. Ruffell
Principal Investigator & Sub-Investigator
Key Appointments:
Lead Psychiatrist, Clerkenwell Health
Lecturer & Researcher in Psychology and Psychedelics, University of Exeter
Chief Medical Officer, MINDS
Visiting Research & Knowledge Exchange Fellow, Goldsmiths, University of London
Honorary Senior Research Fellow, University of Melbourne
Former Senior Research Fellow / Associate, Psychedelic Trials Group, King’s College London
Former CMO & Senior Research Fellow, Psychae Institute
Years of Experience:
10+ years specialising in psychedelic-assisted therapy, psychiatric research, and CNS clinical trials
Therapeutic Areas (CNS & Psychiatry):
Treatment-Resistant Depression, Major Depressive Disorder, Generalised Anxiety Disorder, PTSD, Complex Trauma, Neuropsychiatric Disorders, Autism-related neuropsychiatry
Drug Classes & Modalities:
Psychedelics (psilocybin/COMP360, DMT/harmala, MM120), NMDA-modulating agents, cannabinoid-based therapeutics, serotonergic modulators, antidepressants, anxiolytics, digital and psychotherapeutic interventions, mind-body modalities, microbiome–brain axis therapeutics (research)
Clinical Trials Experience:
PI/Sub-I on multiple Phase II–III psychedelic trials, including COMP360 for TRD and MM120 for GAD
Designed and oversaw Phase I DMT/harmala studies
Senior research roles in psilocybin trials at King’s College London
Experience across more than a decade of psychiatric and therapy-assisted research
Specialist duties include psychiatric oversight, consent, complex rating scales, safety monitoring and therapist training
