How to join a psychedelic clinical trial?
In most countries, clinical trials are the only way to receive psychedelic therapy in a medical setting. If you’re interested in participating in one but not sure how, this comprehensive guide will walk you through what you need to know.
As psychedelic drugs become more acceptable and mainstream, an increasing number of clinical trials are exploring their potential to enhance mental healthcare. Participating in a psychedelic clinical trial not only allows individuals to actively contribute to cutting-edge research, but also offers a potential gateway to innovative treatments for diverse mental health disorders.
The process of joining a clinical trial can seem confusing; therefore, this guide aims to lead you through each step, ensuring a seamless and well-informed journey.
Step 1: Finding a Trial
Unlike some other medical fields, there is not a universal hub where you can find all available clinical trials neatly laid out. Websites attempting to collate this information do exist, such as Psychedelic Support, but it is important to note that these resources might not be comprehensive, entirely up to date or clear about where to sign up.
To navigate this intricate maze, signing up with Contract Research Organisations (CROs) like Clerkenwell Health is a useful approach. CROs conduct trials for numerous drug developers and are often on the lookout for participants for different trials. Additionally, academic institutions like Imperial College London are worth keeping an eye on, though the majority of trials running at the moment are industry-led, highlighting the importance of following CROs.
Step 2: Signing Up
When you sign up to a CRO, you’re often added to a general patient database, where researchers match eligible participants with a suitable trial. Before signing up to a trial or to a database of participants, it is a good idea to understand the organisation or the study
Trial Purpose & Eligbility
Is the trial relevant for your particular circumstance and diagnosis? Each trial operates under distinct eligibility criteria tailored to ensure the safety and relevance of the research. These criteria encompass factors such as age, medical history, current medications, other mental health diagnoses, and use of recreational drugs. Meeting these criteria not only ensures your safety but also enhances the trial's ability to generate accurate and meaningful results. It is important to note that trials will independently verify your information with your GP and will also perform an examination and blood tests (including drug testing) to ensure your safety.
Research Team
Learn about the researchers and clinicians involved. Look for experienced professionals with a solid reputation in the field. A research team with a high reputation indicates commitment to ethical practices and the wellbeing of participants. Look for their published works, academic affiliations, and any past involvement in similar research. Understanding the expertise of the team not only instills confidence in the trial’s integrity but also ensures that you are under the care of skilled and compassionate professionals dedicated to your mental health journey.
Psychedelic Substance
Familiarise yourself with the substance being studied. Understand the unique properties and potential therapeutic effects these substances might have on mental health. Research reputable sources, scientific studies, and participant testimonials to gain a comprehensive understanding. Being well-informed empowers you to make educated decisions, ensuring you are prepared for the experience and can actively engage in discussions with the research team.
Step 3: Consultation
After identifying a trial that aligns with your needs, take the initiative to register interest and enquire about trial specifics. Remember, this interaction is mutual- it is an opportunity for both you and the research team to assess compatibility. The initial stage will involve filling out a form, leading to a potential phone assessment by the research team, either promptly or at a later date based on ongoing studies.
During the conversation, be open and honest about your medical history, current medications, and mental health condition. This transparency is vital; it allows the research team to comprehensively evaluate your suitability for the trial. Prepare any questions you may have about the trial process, the psychedelic substance involved or potential outcomes. This dialogue lays the foundation for a trusting partnership, ensuring both your expectations and the research team’s objectives are in harmony throughout your participation.
Step 4: Informed Consent
Before participating, you will be asked to provide informed consent. This involves receiving detailed information about the trial's purpose, procedures, potential risks, benefits, and your rights as a participant. Take your time to review all the provided information and ask any questions you may have. Only proceed when you fully understand and are comfortable with the details.
Step 5: Screening and Assessment
Clerkenwell Health’s psychedelic clinical trial site in Central London.
If you meet the initial eligibility criteria, you will undergo a thorough screening process, which may involve medical exams, psychological assessments, and interviews. Be prepared that this process is a thorough process and can take up to half a day. It is vital you uphold full transparency during this stage to ensure your own safety throughout the trial.
Step 6: Treatment Sessions:
After enrolment into the trial, you will participate in treatment sessions where the psychedelic substance (or active placebo if it is a placebo-controlled trial) will be administered to you in a controlled and supervised setting. If you receive the placebo, remember that you will still receive high-quality care including medical assessments and psychological support. It is also important to note that the number of sessions can vary based on the trial's design and goals. Thus, it is crucial to be well-informed about the commitment you are making. Understanding the frequency and duration of these sessions ensures you are mentally and logistically prepared.
Step 7: Follow-up
Following the treatment sessions, most trials involve follow-up assessments to monitor your progress and assess the medium-term effects of the treatment. Your continued participation in these assessments is invaluable; it not only contributes significantly to the research's success but also ensures a comprehensive understanding of the treatment's impact over time.
During these follow-up sessions, you will have the opportunity to discuss your experiences and any changes in your mental health and overall wellbeing. This open dialogue is essential, as it provides researchers with vital data to refine their methods and improve the effectiveness of psychedelic therapies.
What’s Next?
Finding and participating in psychedelic trials can feel overwhelming and demands a lot of patience. Participation in these trials does not happen overnight and you might find yourself ineligible until a suitable trial comes up or possibly for any clinical trial due to their strict inclusion criteria. If you can’t join a trial, don’t be discouraged. Once there is sufficient evidence for the safety and effectiveness of these treatments, they will be accessible to everyone within health systems.
If you are interested in exploring further, we invite you to consider the opportunities at Clerkenwell Health. Our commitment to pioneering research, ethical practices, and individual wellbeing defines our approach to mental health care. With your help, we can uncover new possibilities, challenge old paradigms, and contribute to the global search for better mental health care.